The characteristics of aging include DNA damage, changes in the epigenome, loss of healthy protein maintenance ability, stem cell failure and the production of inflammatory molecules… etc. The key to anti-aging is to activate vitality genes, which are both the cause and reversal of aging. The key to aging. NAD+ is the substrate of the DNA repair protein PARP1 and the activator of the longevity gene SIRT1, which plays a key physiological function. However, during the aging process, the content of NAD+ will rapidly decrease, which directly leads to a significant decrease in the activity of SIRT1, which affects mitochondrial function, and reduces the power of the “cell’s power plant”, leading to aging. This explains the relationship between aging and NAD+. And many scientific research experiments have consistently confirmed that maintaining sufficient NAD+ in cells and maintaining the energy of the “cell power plant” mitochondria is the key to inhibiting aging.
As we age, our body’s NAD+ does not work well: when we are 50, the amount of NAD in our body is half of what it was when we were 20, so the cells in our body will forget what they should be doing. Aging begins here. Aging is also accompanied by various diseases. Aging is a disease and it can be cured. As long as aging is treated, the disease can be combated!
NAD+ is the central molecule in the human body, which controls the activity and amount of mitochondria and provides 95% of the body’s energy. At the same time, it can repair damaged DNA in cells and activate Sirtuins longevity genes. But NAD+ declines with age, leading to aging. NMN is the precursor of NAD+. Professor David Sinclair found that supplementing with NMN can increase the level of NAD+ in the body and achieve the effect of reversing aging!
The mechanism of rejuvenation of NMN is: NMN -> convert to NAD+ -> start Sirtuins1~7 longevity gene + activate mitochondria + repair cell DNA + stem cell activation + telomere length maintenance + autophagy increase + immune regulation increase + infertility Reduce -> Healthy and Longevity + Becoming Young + Decrease the Speed of Aging + Restore Youth
NMN four manufacturing methods
(1) Chemical synthesis:
Non-biological natural synthesis method, through trityl ribose or acetyl ribose as starting materials, through bromine substitution, nicotinamide substitution, deacetylation, debenzylation, phosphorylation and other reaction steps Get NMN.
(2) Enzyme synthesis:
Using nicotinamide, adenosine triphosphate, ribose, etc. as starting materials, using various biological enzymes and NAMPT for catalysis to obtain NMN, the reaction conversion rate can reach 80% to 100%. Among them, the Nobel Prize-winning enzyme directed evolution technology, SPT synthetase technology, and RNA biocatalysis technology are more advanced technologies.
(3) Lactic acid bacteria fermentation:
Fermentation with lactic acid bacteria is also one of the manufacturing methods of NMN. For example, in April 2021, Shizuoka University in Japan revealed the method of producing NMN by lactic acid bacteria in the journal Scientific Reports. Find out 3 kinds of anaerobic lactic acid bacteria. During the fermentation process, adding fructose will cause NMN and NR to accumulate in the cells.
(4) Escherichia coli gene engineering:
NMN can also be obtained through Escherichia coli microbial technology. For example, in 2018, the University of Bucharest in Romania stated in the Journal of Scientific Reports that the method of purifying NMN from bacteria was described. Also in May 2021, Kobe University in Japan published a paper in the Journal of Metabolic Engineering, titled: Design of selective production of NMN from glucose and NAM (nicotinamide). They used E. coli to develop a whole-cell biocatalyst that can efficiently produce NMN from cheap raw materials glucose and NAM (nicotinamide).
Among the NMN products currently on the market in 2022, the NMN manufactured by enzymatic synthesis has the most stable quality, the highest purity and activity, and the best bioconversion rate!
The functions of NMN are as follows:
- NMN reverses muscle aging and prevents radiation.
- NMN reverses vascular aging, regenerates blood vessels, and has a significant protective effect on cerebral blood vessels.
- NMN stabilizes telomeres, enhances gene repair, and improves basic metabolism
- NMN hangover and protect liver,
- NMN improves depressive behavior
- NMNImprove sex hormone
- NMN improves sexual function, improves kidney function, restores energy and enhances physical strength.
- NMN boosts immunity, fights viruses and cancer
Reference: https://www.victornmn0520.com/%E7%A5%9E%E5%A5%87%E7%9A%84nmn
