Viruses are obligate intracellular parasites. They rely heavily on the host to replicate and produce new offspring. To achieve this goal, viruses have evolved many clever strategies to subvert and utilize the different cellular mechanisms and processes of their unwilling hosts. In addition, they often use an amazing amount of protein to accomplish this feat. Among the different systems of cells, the cytoskeleton is usually one of the first hijacked systems, because it provides a convenient transport system for viruses and can reach their replication sites relatively easily. In the later stages of the replication cycle, the cell of skeleton also provides an effective means for the newly assembled virus progeny to reach the plasma membrane and leave the infected cell. Nevertheless, with regard to the role of signal transduction and host cytoskeleton in promoting virus transmission and pathogenesis, the cell cytoskeleton is related to promoting virus transmission. Therefore, the Cancer Cell Cytoskeleton program running in Spooky2 may be treatable to Cancer Virus, which maybe a good try.
